Intrastimulation discharges during electrical stimulation mapping May help identify seizure onset network

Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression.

Since neuronal excitability is sensitive to changes in extracellular pH and there is regional diversity in the changes in extracellular pH during neuronal activity, we examined the activity-dependent extracellular pH changes in the CA1 region and the dentate gyrus. In vivo, in the CA1 region, recurrent epileptiform activity induced by stimulus trains, bicuculline, and kainic acid resulted in bi...

In vivo neuronal firing patterns during human epileptiform discharges replicated by electrical stimulation

OBJECTIVE To describe neuronal firing patterns observed during human spontaneous interictal epileptiform discharges (IEDs) and responses to single pulse electrical stimulation (SPES). METHODS Activity of single neurons was recorded during IEDs and after SPES in 11 consecutive patients assessed with depth EEG electrodes and attached microelectrodes. RESULTS A total of 66 neurons were recorde...

Case-finding instruments may help identify depression in primary care.

Seizure-related automatic locomotion triggered by intracerebral electrical stimulation.

We describe the case of an eight-year-old boy, who underwent a video-stereo EEG (SEEG) investigation for the presurgical assessment of drug-resistant epilepsy, related to a right fronto-lateral cortical dysplasia and who became seizure-free after epilepsy surgery. The unexpected finding of the investigations was that intracerebral, high frequency (50 Hz) electrical stimulation (HFS) triggered t...

EEG onset of a seizure during TMS from a focus independent of the stimulation site.

The risk of a seizure in temporal association with a TMS session in a patient with epilepsy is less than 2%, both for single and paired-pulse TMS (Schrader et al., 2004) and for repetitive TMS (rTMS) (Bae et al., 2007). With rare exceptions (Dhuna et al., 1991), TMS-associated seizures in epilepsy patients have been clinically similar to the patients’ typical spontaneous seizures, leaving uncer...